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Xd = rdcos, Yd = rd sin , whererd = Jx~ + YJ and, = tan- 1 (Yd/Xd). Then calculate a = cos- 12 rd/d. Generate a random number u between 0 and 1. If 0 :s; u < 0.5, = , - a. If 0.5 :s; u :s; 1, = a. The coordinates (x~, Y~) are then

Step 5. It is possible that the new position of the displaced disk may overlap with other disks in the system. We check overlap similar to what is done in Section 2.1 for hard cylinders. If there is no overlap, we will accept the move and update the coordinates of the displaced disk. Otherwise, reject the displacement and return the test disk to its original position. As in the case of sticky sphere, we have to maintain an updated catalog of the system's binding configuration, so that we need to rebuild the list of possible doublebond candidates whenever a trial move of the test disk is successful. In Figs. 9.2.5 and 9.2.6, we illustrate the Monte Carlo simulations of the pair distribution functions for the two-dimensional sticky disks. The result in Fig. 9.2.5 is for the case of 200 sticky disks and fractional volume of 20%. For Fig. 9.2.6, we use 300 sticky disks for the fractional volume of 30%. The Monte Carlo results are obtained by averaging over 12000 and 10000 passes, respectively. For both cases, the sticky paramter is T = 0.1. Compared with the 3-D results shown in 8, the 2-D sticky disks exhibit discontinuities in the pair distribution functions at pair separations of r = V3d, /7 d, and 3d in addition to r = d and 2d. These features have also been shown in the study of Seaton and Glandt [1986] for adhesive disks.

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Consider a cylinder of permittivity Ep and radius a centered at the origin (Fig. 9.3.1). Let the incident wave have exp(ikizz) dependence. The incident wave is given by

(9.3.1)

~1.5

5 Select Object for object binding, and click Next The second page of the Data Source Con guration Wizard, shown in Figure 72, provides the list of classes for your selection

Figure 9.2.5 Pair distribution function obtained from Monte Carlo simulations for a system of single size sticky disks with T = 0.1 and f = 0.2. 200 disks are used in the simulations, and the results are obtained by averaging over 12000 passes.

3 ----.----,---,-----,---------,---,---,--_

One mechanism for extending the patents on a blockbuster drug is obtaining supplementary protection This added patent protection, which can extend a patent up to ve years, is a means of compensating pharmaceutical rms for loss of market exclusivity during a lengthy reg ulatory review process Another approach is to acquire orphan drug des ignation from the Of ce of Orphan Products Development at the FDA for drugs with a market potential limited to fewer than 200,000 pa tients The Orphan designation, available since 1983, quali es the phar maceutical rm for seven years of marketing exclusivity, with a 50 percent tax credit for research expenses, and a waiver from certain FDA fees in exchange for developing the drug The drug must then go through the new drug approval process like any other drug.

~1.5

Figure 9.2.6 Pair distribution function obtained from Monte Carlo simulations for a system of single size sticky disks with T = 0.1 and f = 0.3. 300 disks are used in the simulations, and the results are obtained by averaging over 10000 passes.

Figure 72 Only the classes that are in the current project or referenced by the current project are displayed

where a~M) and a~N) are the TE and TM wave coefficients and the regular vector cylinderical waves RgM nand RgN n are defined in 1, Section 4.2 of Volume I. In (9.3.1),

(9.3.2)

11,=-00

[a~M)S M 11,(kip , kiz , r) + a}['l)s N 11,(kip , kiz , r)]

7

(9.3.3)

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