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NET Framework signi es that the system assemblies and the base classes will be reliably consistent types In short, there is little that is COM-based ADO in ADONET from a technical perspective Only from a functional perspective is ADONET a natural progression from ADO A new technology was required to overcome the limitations of ADO performance and scalability a technology that provided the developer with a variety of execution options ADONET was designed to both overcome ADO limitations and leverage the developer s ADO skills The basic objects of ADO are found in ADONET Commands executed on connections to data providers are used in ADONET with only slight differences from the commands executed on connections to data providers used with ADO However, with ADONET, developers have greater control over how the data will be retrieved and manipulated Execution can be asynchronous and batched.

Figure 712 Chugai model PAMPA permeabilities as a function of pH for several drug molecules [561]

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Results can be elegantly stored and manipulated at the application, disconnected from the database Alternately, results can as easily be streamed as binary data or as XML Many developers labor under the misconception that ADONET is simply the upgrade to ADO ADO was developed to support client/server applications and presupposes that the user and the data will both remain connected to the application for the lifetime of an execution cycle At the risk of oversimplifying the difference, ADO held state in the data source and ADONET is built to be able to maintain state disconnected from the database One advantage for NET is that there is no requirement that the database remain connected to the application for the complete execution cycle In part, this design goal is realized because XML technology is fundamental to ADONET To a larger degree, state is managed in the ADO.

the donor and acceptor sides varied with position in the GIT, as indicated in Table 72 Others have measured microclimate pH as low as 52 [73] Yamashita et al [82] determined drug permeabilities by performing Caco-2 assays under two pH conditions: pH 60donor 74acceptor and pH 74donor 74acceptor These choices adequately span the microclimate range in the GIT Weak acids were more permeable under the gradient-pH condition, compared to the iso-pH condition Weak bases behaved in the opposite way Uncharged molecules showed the same permeabilities under the two conditions The gradient-pH set of permeability measurements better predicted human absorption than the iso-pH set (r 2 085 vs 050, respectively) The authors may have underestimated some of the permeabilities, by using equations which implied iso-pH conditions (see, Section 75) In designing the ideal screening strategy, it appears important to consider using pH gradients If the in vivo conditions are to be mimicked, at least two effective permeability measurements should be attempted, as suggested by the above mentioned researchers: pH 60donor 74acceptor (gradient pH) and pH 74donor 74acceptor (iso-pH), the microclimate pH range spanned in the GIT

NET application layer by the local application cache known as the DataSet class In ADONET 20 and later, state management is further extended with asynchronous command execution and Multiple Active Result Sets (MARS) The following sections describe ADONET objects, keeping ADO objects in perspective, and point out the new features in the ADONET 35 release In other words, the discussion builds on the ADO information presented earlier in this chapter as ADONET concepts are introduced ADONET is a managed object model with functional capabilities much like the classic ADO, yet designed to enable more scalable applications, particularly in the disconnected environments found in many n-tier, SOA, Web Services, and ASPNET applications..

TABLE 72 Microclimate pH on the Apical Side of Epithelial Cells in the GIT in Rats Position in the GIT Stomach Proximal duodenum Distal duodenum Proximal jejunum Midjejunum Distal jejunum Proximal ileum Midileum Distal ileum Proximal colon Distal colon

the triangular wave would have. The importance of peak amplitude limits and peak power limits in circuit design must always be kept in mind. BASIC PRINCIPLES OF THE HILBERT TRANSFORM There are many types of transforms that are useful in electronics work. The DFT and IDFT are well known in this book because they transform back

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